Why test an AI on medical questions?
Large language models are programs trained on huge amounts of text to write answers in everyday language. Many people already ask them health questions.
In medicine, a wrong answer can cause harm. The authors note that the usual tests are often limited to multiple-choice questions marked automatically, which is not enough to judge whether an answer is safe and useful.
How was the study done?
The Google team built MultiMedQA, a collection of seven question sets: medical exam questions, research questions and questions from the public. One of them, HealthSearchQA, holds 3,173 health questions that people commonly type into search engines.
They tested PaLM, a model with 540 billion parameters (its internal settings), and Flan-PaLM, a version trained to follow instructions. Then they built Med-PaLM, a version adapted to medicine using a few examples written by doctors.
Beyond quizzes, doctors reviewed the longer answers against several criteria: accuracy, understanding, reasoning, possible harm and bias.
What did the study find?
On US medical licensing exam-style questions, Flan-PaLM scored 67.6%, more than 17 points above the best result published until then.
But the doctors' review showed gaps. Only 61.9% of Flan-PaLM's longer answers were judged in line with scientific consensus, and 29.7% could lead to harm.
With Med-PaLM, 92.6% of answers were in line with consensus, on a par with answers written by doctors (92.9%). Potentially harmful answers fell to 5.9%, close to doctors (5.7%). Even so, the authors conclude that Med-PaLM remains inferior to clinicians.
Key figures
- 67.6%Flan-PaLM's score on US medical licensing exam-style questions
- 61.9% then 92.6%of longer answers in line with scientific consensus, Flan-PaLM then Med-PaLM (doctors: 92.9%)
- 29.7% then 5.9%of answers judged potentially harmful, Flan-PaLM then Med-PaLM (doctors: 5.7%)
An AI that knows things is not your doctor
This study shows that an AI can do well on exam questions and still sometimes give risky answers. Mima is not a doctor and does not make diagnoses.
Mima gives you clear, simple explanations about your symptoms and treatments, and helps you note what you do not understand so you can ask your care team. A good question to keep for the appointment: "I read this, does it apply to my situation?"
What does this mean for patients?
This study puts no tool in patients' hands. It shows that these models hold a lot of medical knowledge, but that a good exam score does not guarantee a safe answer.
Above all, it offers a way to evaluate these tools with doctors, beyond quizzes. For patients, the message is clear: an AI answer can help you understand something or prepare a question, not replace a clinician's advice.
What are the limits of this study?
The questions are tests, not real patients with their history, results and treatments. Passing a quiz says nothing about the ability to care for someone.
The authors describe the doctors' review as a pilot evaluation, on a limited number of answers and reviewers. They call for further evaluation, especially on safety, fairness and bias. And these models change fast: the figures describe the 2023 versions.
Frequently asked questions
Can AI pass the US medical licensing exam?
In this study, Flan-PaLM scored 67.6% on US exam-style practice questions. These are not the official exam, and a good score does not make it a doctor.
Can I trust an AI with a health question?
Not on its own. Before tuning, 29.7% of the model's longer answers were judged potentially harmful. Check any AI answer with a health professional.
What is Med-PaLM?
A version of Flan-PaLM that Google adapted to medicine using examples written by doctors. The authors call it encouraging but inferior to clinicians.
What is a large language model?
A program trained on huge amounts of text to understand a question and write an answer in everyday language, like the chatbots the public uses.
The original study
Singhal K, Azizi S, Tu T, et al. “Large language models encode clinical knowledge” Nature, July 12, 2023. DOI : 10.1038/s41586-023-06291-2
Read the full study in NatureThis article summarizes a scientific study and is not medical advice.